Are you not able to open up Microsoft Office Outlook 2010? We have given some best solutions to fix the issue cannot start Microsoft Outlook 2010.
You could see this error when you try to open Outlook and it keeps loading for a while before the error pops-up. Microsoft has come out with findings that this happens because of a corrupted Outlook profile file.
However, the other reasons would be, attempting to run Outlook in Compatibility mode, using a profile file with the extension ‘.pst’ or ‘.ost’, which was created in an older version of Outlook.
To fix the issue cannot start Microsoft Outlook 2010, perform the solutions suggested here.
The Outlook Inbox Repair tool will help you to restore Outlook data files (.pst and .ost) that have been corrupted when uninstalling or reinstalling Outlook.
File corruption is also one of the reasons for this problem. Repairing the Navigation Pane will help you to open Outlook 2010 again.
Sometimes an extension or plug-in you installed could create a problem in opening the Outlook 2010. This can be undone by running Outlook in Safe Mode, which will disable your software's non-default elements.
If Outlook opens in Safe Mode, then the add-ins are the cause of the problem. So you can eliminate this issue by deleting the add-ins one by one until the problem is resolved.